A class of antidepressants known as SSRIs or selective serotonin reuptake inhibitors are often used to delay ejaculation.  This just happens to be one of the side effects of this class of drugs that may be taken advantage of in the treatment of premature ejaculation.

They are not FDA approved for the treatment of premature ejaculation; at this time no drug is.  They are however FDA approved for depression, so it constitutes a legal but off label use of the medication.

Several medications in this class are used for this purpose, including, Zoloft®, Paxil® and Prozac®.  We usually use Zoloft®, because we have seen the best results with it.

Another class of drugs, tri-cyclic antidepressants are also sometimes helpful.  Anafranil is one such example.

It is usually not necessary to take these drugs every day to have a beneficial effect.  * It is usually recommended to take the medicine 1-2 hours before sexual intercourse is anticipated.

These medications will often allow a man to have substantially better control of when he ejaculates.

These medications are quite safe, but have some possible undesirable side effects.  Some of the side effects include, dry mouth and eyes, depression, suicidal ideology, erectile dysfunction, nausea, drowsiness and decreased libido.

* Men who have a previous or current history of depression or mental illness and men under the age of 25 should not use these medications to treat premature ejaculation.

*  While we will certainly try to help all of our patients, as with any medical treatment, there is no guarantee of specific results, as results can and usually do vary from patient to patient. All numbers and time frames mentioned are approximate and may vary from patient to patient.





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